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September 25, 2025CureusOpen Access

Macrolide-Resistant Mycoplasma pneumoniae Infection Successfully Treated With Doxycycline and Immunomodulators in a Pediatric Patient: A Case Report

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Authors

MWMekdes M WollelMYMuluneh A YimerKYKathy Yimer

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Overview

Case report reveals successful treatment of pneumonia with doxycycline and immunomodulators, suggesting effective alternatives to macrolide therapy.

Key Points

  • Doxycycline and immunomodulators improved symptoms in a young patient with macrolide-resistant pneumonia.
  • The patient, initially treated with azithromycin, still tested positive for mycoplasma infection using multiplex PCR.
  • Significant improvements in the patient’s condition occurred rapidly within 72 hours of initiating doxycycline treatment.
  • The case underscores the importance of recognizing resistance and the potential benefit of adjunctive therapies in pneumonia management.

Cite This Study

Wollel et al. (2025) studied this question.

synapsesocial.com/papers/68d5d0d7ddad3c16d4635ae3https://doi.org/10.7759/cureus.92977
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Mycoplasma pneumoniae Pneumonia: Variety of Presentation in Children Case Series2025
  2. 2Efficacy and safety of doxycycline for severe Mycoplasma pneumoniae pneumonia in pediatric patients2025
  3. 3Comparative study of clinical characteristics and long-term prognosis between macrolide-resistant and macrolide-sensitive Mycoplasma pneumoniae infections in children: A retrospective case-control study2025
  4. 4Adult Hospitalized Mycoplasma Cases in a Tertiary Hospital in Japan.2025
  5. 5Effect of Macrolide Resistance and Mycoplasma pneumoniae DNA Load in Bronchoalveolar Lavage Fluid on Immune and Inflammatory Responses in Children with Mycoplasma pneumoniae Pneumonia2025