September 25, 2025Archiv der Pharmazie

Validated Stability‐Indicating RP‐HPLC Method for Nirmatrelvir in Self‐Emulsifying Drug Delivery Systems: Formulation Characterization and Permeability Enhancement

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Nirmatrelvir showed a fivefold increase in permeability across Caco‐2 cell monolayers compared to tablets.
The HPLC method demonstrated excellent linearity (R² = 0.9999) and accuracy (98.6%–100.2%) in assessing nirmatrelvir stability.
Formulation using Labrafac MC 60 and Transcutol HP yielded a nanoemulsion with low polydispersity index (0.189 ± 0.023).
Forced degradation studies confirmed stability under various conditions, highlighting the robustness of the developed method.

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Implication

Novel method shows improved permeability and stability for nirmatrelvir in self-emulsifying drug delivery systems, indicating effective formulation strategies.

Cite This Study

Patel et al. (2025) studied this question.

synapsesocial.com/papers/68d5bd72dc445aa9033b0e6e https://doi.org/10.1002/ardp.70100

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Implication

Novel method shows improved permeability and stability for nirmatrelvir in self-emulsifying drug delivery systems, indicating effective formulation strategies.

Validated Stability‐Indicating RP‐HPLC Method for Nirmatrelvir in Self‐Emulsifying Drug Delivery Systems: Formulation Characterization and Permeability Enhancement

Key Points

Discussion

Implication

Cite This Study

Validated Stability‐Indicating RP‐HPLC Method for Nirmatrelvir in Self‐Emulsifying Drug Delivery Systems: Formulation Characterization and Permeability Enhancement

Key Points

Discussion

Implication

Cite This Study

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