Design Development and Evaluation of a Gastroretentive Floating Drug Delivery System of Dolutegravir for Enhanced Bioavailability

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The optimized gastroretentive formulation achieved a cumulative drug release of 94.32% over 12 hours.
Formulation F7 showed a floating lag time of less than one minute, indicating effective gastric retention.
The study evaluated various polymeric formulations, focusing on the balance of drug-to-polymer ratios for optimal performance.
Results suggest that floating tablets can significantly enhance the therapeutic performance of dolutegravir and patient compliance.

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Formulation improves bioavailability in patients using dolutegravir for HIV therapy, suggesting enhanced drug retention.

Shareef et al. (2025) studied this question.

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