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September 25, 2025World Journal of Clinical OncologyOpen Access

Emerging multifaceted roles of the microbiome in cancer susceptibility

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Authors

HCHang‐Seok ChangJPJesús Pérez‐LosadaJMJianhua Mao

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Overview

This review highlights microbiome roles and gene-microbiome interactions in cancer risk, suggesting preventive interventions.

Key Points

  • The microbiome significantly influences cancer susceptibility through various mechanisms, including immune modulation.
  • Identification of genetic variants linked to cancer risk is accelerated by next-generation sequencing technologies.
  • Despite identifying numerous cancer-susceptibility genes, much of the overall cancer risk remains unexplained—known as missing heritability.
  • Current research emphasizes the need for advanced models and tools, like collaborative cross mice and artificial intelligence, to better understand microbial influences.

Cite This Study

Chang et al. (2025) studied this question.

synapsesocial.com/papers/68d5bd72dc445aa9033b0cb9https://doi.org/10.5306/wjco.v16.i9.111379
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Microbial Omens: The Predictive Power of Microbiome Signatures in Cancer Risk2025
  2. 2The microbiome in cancer2025
  3. 3Microbiome modulation of tumorigenesis and immune responses2026 · 16 citations
  4. 4Genetically proxied gut microbiota and cancer risk: a scoping review of Mendelian randomization studies2025 · 4 citations
  5. 5The Microbiome Shaping Cancer Development, Progression, and Therapeutic Response2025