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September 10, 2025Physiological GenomicsOpen Access

The Microbiome Shaping Cancer Development, Progression, and Therapeutic Response

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Authors

RSRana Salihoğlu

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Overview

This review highlights how the microbiome influences immune dynamics and therapeutic response in cancer, suggesting a significant role in tumor progression.

Key Points

  • The microbiome is a key player in shaping cancer biology and tumor progression across multiple malignancies.
  • Recent findings indicate that microbial communities affect therapeutic responses, particularly through immune checkpoint blockade efficacy.
  • Causal and spatially resolved frameworks can utilize microbiome insights to enhance precision oncology approaches.
  • Microbial metabolites and intratumoral colonization significantly influence host immune phenotypes, establishing the microbiome's role in cancer treatment.

Cite This Study

Rana Salihoğlu (2025) studied this question.

synapsesocial.com/papers/68c23abeb210217d6478217dhttps://doi.org/10.1152/physiolgenomics.00091.2025
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Also Consider

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  1. 1The microbiome in cancer2025
  2. 2Microbiome modulation of tumorigenesis and immune responses2026 · 16 citations
  3. 3Role of gut microbiota in cancer modulation: molecular mechanisms and emerging therapeutic strategies2026 · 1 citations
  4. 4The microbiome and lung cancer: microbial effects on host immune responses and treatment outcomes2025 · 2 citations
  5. 5The mechanisms and therapeutic potential of the microbiome-immune interface in cancer2025