Novel multi-epitope peptide vaccine design and validation using bioinformatics approach targeting MSP-1 protein of Knowlesi malaria

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Discussion

Bioinformatics approach identified immunogenic epitopes in MSP-1, suggesting potential vaccine efficacy.

The constructed multi-epitope vaccine was predicted to have 98.89% global population coverage and strong immunogenic potential.
Molecular docking confirmed a stable interaction between the vaccine candidate and Toll-like receptor 4.
In silico simulations indicated significant activation of T cells and robust antibody production against Plasmodium knowlesi.
The study highlights the promising design of a multi-epitope vaccine, though further experimental validation is needed.

Oktomalioputri et al. (2025) studied this question.

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