August 3, 2025Open Access

Computational Prioritization of T Cell Epitopes to Overcome HLA Restriction and Antigenic Diversity in Plasmodium falciparum

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Computational tool identifies conserved T cell epitopes in Plasmodium falciparum, highlighting HLA coverage and immunogenic potential.

A computational tool prioritizes T cell epitopes to address HLA restriction and antigenic diversity in Plasmodium falciparum.
TEpiNom identifies 2,265 MHC I and 1,992 MHC II conserved epitopes across multiple parasite life stages.
The tool integrates HLA allele frequencies from sub-Saharan Africa to maximize vaccine population coverage.
This approach enhances malaria vaccine design by focusing on epitope promiscuity and multi-stage antigen selection.

Laurenson et al. (2025) studied this question.

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