September 25, 2025Open Access
The effect of family history and polygenic risk scores on general and abdominal obesity in the Lifelines Cohort Study
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Implication
Observational study reveals polygenic risk scores and family history influence obesity metrics, suggesting combined genetic contributions.
Key Points
- The combination of polygenic risk scores and family history explains 11.81% of variability in body mass index.
- Family history adds unique predictive value to obesity indices beyond what polygenic risk scores provide.
- Linear mixed regression models showed that both maternal and paternal obesity metrics significantly influenced offspring's obesity measures.
- Similar effect sizes for between- and within-family PRS suggest minimal bias from gene-environmental correlations.
Cite This Study
Wang et al. (2025) studied this question.