August 3, 2025Open Access

A multi-ancestry polygenic risk score for body mass index predicts longitudinal weight change

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Ancestry-specific polygenic risk scores predict weight change in diverse groups, suggesting new approaches for obesity risk assessment.

The multi-ancestry polygenic risk score (MAPRS) predicts weight change reliably across diverse ancestries.
MAPRS explains 7.05% of the variance in BMI in a large-scale population study from the NIH All of Us program.
A one standard deviation increase in MAPRS is linked to a 0.16 kg/m² increase in future BMI and higher odds of significant body weight gain.
Most clinical risk factors showed weaker associations with weight change compared to the robust MAPRS findings.

Lu et al. (2025) studied this question.

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