September 25, 2025Scientific ReportsOpen Access

Plasticity of interhemispheric motor cortex connectivity induced by brain state-dependent cortico-cortical paired-associative stimulation

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Long-term strengthening of interhemispheric inhibition was observed, enhancing connectivity between motor cortices.
Repetitive paired associative stimulation during different µ-rhythm phases showed no differential effects on SIHI.
Cortico-cortical paired associative stimulation reveals important interactions between corticospinal and M1-M1 connectivity.
Applications may include therapeutic strategies aimed at modifying the excitation/inhibition balance between hemispheres.

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Investigating the impact of µ-rhythm phase on interhemispheric inhibition in healthy subjects, revealing potential therapeutic applications.

Ermolova et al. (2025) studied this question.

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Investigating the impact of µ-rhythm phase on interhemispheric inhibition in healthy subjects, revealing potential therapeutic applications.