September 23, 2025Journal of Clinical MedicineOpen Access

Pro-Inflammatory Cytokines as Early Predictors of Chronic Rheumatologic Disease Following Chikungunya Virus Infection

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Discussion

Literature review evaluates cytokine profiles and their relationship with arthritis outcomes, suggesting chronic risks.

Findings indicate that elevated levels of IL-6 and TNF-α are associated with chronic arthritis in CHIKV patients.
A total of 21 studies included 4216 participants, highlighting a substantial link between cytokine levels and chronic symptoms.
Observational cohorts assessed cytokine levels during acute and chronic CHIKV phases, presenting diverse assay methodologies.
Importance of identifying cytokine biomarkers is emphasized for better understanding chronic inflammatory conditions post-CHIKV.

Conforti et al. (2025) studied this question.

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