September 10, 2025VirusesOpen Access

Monocyte Dynamics in Chikungunya Fever: Sustained Activation and Vascular-Coagulation Pathway Involvement

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Chikungunya fever patients exhibited sustained activation of monocytes, indicating persistent immune response.
Significantly elevated sCD163 levels were observed, reflecting ongoing monocyte/macrophage activation in infection.
Non-classical monocytes showing increased TLR4 and TLR7 expression were linked to distinct clinical manifestations like edema and arthritis.
Elevated tissue factor and related coagulation mediators were noted, despite a low incidence of bleeding complications.

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This analysis examines monocyte dynamics and coagulation involvement in chikungunya fever patients, suggesting immune dysfunction.

Fernandes-Santos et al. (2025) studied this question.

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