Synapse
⌘+K
Synapse
PulseExploreJournal ClubResearchersJournals
Instagram
HomeJournal ClubExplore
September 23, 2025AntioxidantsOpen Access

Betulinic Acid-Enriched Dillenia indica L. Bark Extract Attenuates UVB-Induced Skin Aging via KEAP1-Mediated Antioxidant Pathways

View Full Paper
Ask AI
Bookmark
Share

Authors

BSBo‐Rim SongSKSunghwan KimSLSang‐Han Lee

Discussion

Loading...

Member takes

Overview

Experimental analysis demonstrates that the extract reduces oxidative stress in skin cells, highlighting its potential as a nutraceutical.

Key Points

  • The extract significantly reduced intracellular reactive oxygen species in keratinocyte cells exposed to UVB.
  • Molecular docking confirmed that betulinic acid binds to KEAP1, implying activation of the Nrf2 pathway.
  • Optimized extraction using ANN modeling yielded high levels of phenolic and flavonoid compounds.
  • These findings suggest the extract may effectively combat oxidative stress and support skin health.

Cite This Study

Song et al. (2025) studied this question.

synapsesocial.com/papers/68d43ed7713b0b5dfea7e589https://doi.org/10.3390/antiox14091144
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Skin-Protective Activities of Dioscorea batatas Decne Peel Extracts with Differential Phenanthrene Contents2026
  2. 2Cosmetic Anti-Aging Potential of the Traditional Thai Longevity Formula Mai-Kae-Den-Klong: Mechanistic Insights from Enzyme-Based Bioassays and In Silico Analysis2026
  3. 3Investigating the pharmacological properties of <i>Eurya nitida</i> Korth. Fruit extracts: promising anti-skin aging and anti-inflammatory effects2025
  4. 4Comparative Study on Antioxidant Potential of Schinus terebinthifolius Extracts Prepared by Conventional Extraction, Accelerated Solvent Extraction, and Pulsed Electric Field Method2025
  5. 5In Vitro and In Silico Evaluation of the Anti-Aging Potential of Eugenia uniflora UAE Extracts2025 · 2 citations