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September 19, 2025APL MaterialsOpen Access

Transactional spinal cord injury repair using water-memory hyperelastic sponge scaffold with inflammatory regulated microenvironment

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Authors

RZRunquan ZhengZYZhenyu YaoJLJiawei Li

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Overview

Experimental approach improves recovery and promotes neuronal differentiation in spinal cord injuries, indicating potential for enhanced treatment.

Key Points

  • Enhanced recovery of motor and sensory functions observed in spinal cord injury treatment.
  • In vivo studies demonstrated significant axonal regeneration and reduced glial scar formation.
  • The combination of silk fibroin scaffolds and exosomes promoted neuronal differentiation effectively.
  • Immune-inflammatory assays revealed transformation of microglia to an anti-inflammatory phenotype.

Cite This Study

Zheng et al. (2025) studied this question.

synapsesocial.com/papers/68d43c79713b0b5dfea7bef6https://doi.org/10.1063/5.0295407
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1<b>Tissue-Engineered Neural Stem Cell Scaffolds in Spinal Cord Injury: Insights into Materials, Molecular Pathways, and Regenerative Applications</b>2025
  2. 2Spinal Cord‐Like Scaffold with Rapid Tissue Integration Enhanced Spinal Cord Nerve Repair2025 · 25 citations
  3. 3Engineered Healing: Synergistic Use of Schwann Cells and Biomaterials for Spinal Cord Regeneration2025 · 9 citations
  4. 4Silk fibroin‐based biomaterials for spinal cord injury repair: Recent advances and future prospects2025
  5. 5Exosome‐Loaded Bioscaffolds for Spinal Cord Injuries: A Review2025 · 4 citations