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September 10, 2025

Tissue-Engineered Neural Stem Cell Scaffolds in Spinal Cord Injury: Insights into Materials, Molecular Pathways, and Regenerative Applications

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Authors

AAAhmed S. AhmedJSJesse R. SchankMRMark M. Rohn

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Overview

Scaffolds facilitate neural recovery in spinal cord injury, highlighting the role of neural stem cells and signaling pathways.

Key Points

  • Scaffold-assisted cell delivery shows functional improvements in spinal cord injury recovery.
  • Neural stem cells differentiate better in scaffolds that mimic the extracellular matrix.
  • Key signaling pathways like Notch and Wnt are explored for guiding stem cell behavior.
  • Immune response and scaffold degradation challenge the clinical application of these technologies.

Cite This Study

Ahmed et al. (2025) studied this question.

synapsesocial.com/papers/68c23d3ab210217d6478cef0https://doi.org/10.64797/jscb.v1i1.9529
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  1. 1Engineered Healing: Synergistic Use of Schwann Cells and Biomaterials for Spinal Cord Regeneration2025 · 9 citations
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  4. 4Transactional spinal cord injury repair using water-memory hyperelastic sponge scaffold with inflammatory regulated microenvironment2025 · 3 citations
  5. 5Advances in Biomaterial Scaffolds for Spinal Cord Tissue Engineering2025