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September 18, 2025AgingOpen Access

Depletion of the TRF1 telomere-binding protein leads to leaner mice with altered metabolic profiles

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Authors

JRJuan RuanoLBLeire BejaranoRSRosa Serrano

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Overview

Study reveals that TRF1 affects metabolism and obesity in mice, suggesting new metabolic roles.

Key Points

  • Trf1-deficient mice demonstrated a leaner phenotype and improved glucose tolerance on a high-fat diet, revealing its new role in metabolism.
  • Research indicates that the absence of TRF1 leads to reduced adiposity, showing the importance of this protein in metabolic regulation.
  • Study explores the relationship between telomeres and obesity, highlighting the unexpected role of TRF1 in regulating metabolic processes.
  • Findings suggest potential therapeutic avenues targeting TRF1 to address obesity-related metabolic disorders.

Cite This Study

Ruano et al. (2025) studied this question.

synapsesocial.com/papers/68d43c79713b0b5dfea7bdcehttps://doi.org/10.18632/aging.206320
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Essential Role for Trf2 in Cardiac Development and Function2025
  2. 2Ret finger protein deficiency attenuates adipogenesis in male mice with high fat diet-induced obesity2025
  3. 3Telomeres control human telomerase (TERT) expression through non-telomeric TRF22025
  4. 4Telomeres control human telomerase (hTERT) expression through non-telomeric TRF22025
  5. 5Time‐restricted feeding combined with exercise improves hepatic and glycaemic metabolism in obese mice: A sex‐dependent study2025 · 7 citations