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August 19, 2025The Journal of PhysiologyOpen Access

Time‐restricted feeding combined with exercise improves hepatic and glycaemic metabolism in obese mice: A sex‐dependent study

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Authors

GAGabriel Calheiros AntunesCCCamila Venturini Ayres CunhaLOLeandro Kansuke Oharomari

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Overview

Experiment shows time-restricted feeding and exercise enhance glycaemic metabolism in obese mice, emphasizing sex-dependent benefits.

Key Points

  • Combining time-restricted feeding with exercise led to improved liver triglycerides and metabolic health.
  • Males exhibited better aerobic exercise performance and regulation of hepatic triglycerides along with improved metabolism.
  • Female mice showed enhanced fasting glucose levels and metabolic responses from the combined approach.
  • Both sexes benefited from the dual strategy, indicating its potential against obesity and MAFLD.

Cite This Study

Antunes et al. (2025) studied this question.

synapsesocial.com/papers/68af35ddcf1dd9ea359e9c8ahttps://doi.org/10.1113/jp287681
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Hypothalamic Gliosis as Potential Mediator of Improved Glucose Tolerance Induced by Time-Restricted Feeding in Obese Mice2025
  2. 2Effects of Combining Exercise and Dietary Shifts on Motor Coordination and Oxidative Markers in a High‐Fat Diet Model in Rats2025
  3. 3Time-restricted feeding leads to sex- and organ-specific responses in the murine digestive system2025
  4. 4Different Fasting Methods Combined With Running Exercise Regulate Glucose Metabolism via <scp>AMPK</scp>/<scp>SIRT1</scp>/<scp>BDNF</scp> Pathway in Mice2025 · 6 citations
  5. 5Effect of Time-Restricted Feeding on Anthropometric, Metabolic, and Fitness Parameters: A Systematic Review2025