Age-related hippocampal connectivity alterations in HCP-Aging dataset

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Aging leads to reduced hippocampal connectivity density and streamline count, suggesting pathway degeneration.
MRI data showed significant alterations in connectivity, with age influencing diffusion characteristics.
The study mapped hippocampal pathways and linked diffusion parameters to cognitive outcomes related to aging.
These findings align with the hippocampal disconnection theory, emphasizing white matter integrity's role in aging.

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Analysis reveals decreased hippocampal connectivity with aging, indicating implications for cognitive decline.

Pang et al. (2025) studied this question.

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