September 11, 2025Journal of Lipid ResearchOpen Access

Long-term Omega-3 Polyunsaturated Fatty Acid Supplementation Improves Meningeal Lymphatic Function During Brain Aging in Mice

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Long-term omega-3 PUFAs supplementation improves motor and cognitive behaviors in aged mice, decreasing age-related decline.
Findings indicate increased levels of DHA and EPA in the brain, along with reduced toxic protein accumulation.
Assessment included control, low-dose, and high-dose groups of omega-3 PUFAs in a structured 12-month dietary trial.
Preservation of meningeal lymphatic function was identified as a key mechanism in mitigating brain aging effects.

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Randomized trial shows Omega-3 fatty acids improve brain function in aging mice, suggesting impacts on lymphatic health.

Liu et al. (2025) studied this question.

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