September 10, 2025The FASEB Journal

FOXO3 Protects Lens Epithelial Cells From UVB‐Induced Oxidative Stress via the AMPK/FOXO3 Signaling Pathway

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Functional assays show FOXO3 mitigates oxidative stress in lens epithelial cells, suggesting new therapeutic strategies for age-related cataract.

FOXO3 significantly increases cell viability and decreases apoptosis in UVB-exposed lens epithelial cells.
AMPK pathway inhibition restored FOXO3 and exacerbated UVB damage, highlighting its role in oxidative stress regulation.
The interaction between FOXO3 and lncRNA SNHG12 influences apoptosis and oxidative stress, marking SNHG12 as a regulatory target.
This research presents FOXO3 as a potential therapeutic target in age-related cataract management.

Sun et al. (2025) studied this question.

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Functional assays show FOXO3 mitigates oxidative stress in lens epithelial cells, suggesting new therapeutic strategies for age-related cataract.