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September 20, 2025NeuropsychopharmacologyOpen Access

Comparative polygenic predispositions of treatment-resistant depression in East Asian and European populations

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Authors

CCChi‐Fung ChengWKWei-Yi KaoMLMei‐Chen Lin

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Overview

Cohort study found polygenic associations for treatment-resistant depression across East Asian and European populations, suggesting genetic insights vary by ancestry.

Key Points

  • The study finds significant polygenic associations influencing treatment-resistant depression across different populations.
  • With a cohort of 106,796 participants, meta-analytic R squared values were 68% for TRD vs. non-MDD and 81% for trMDD vs. non-MDD.
  • Investigating genetic predispositions, the cohort study utilized data from Taiwan Biobank to explore treatment-resistant depression in a diverse population.
  • Trans-ancestry genetic estimates showed moderate to high concordance, indicating the need for population-specific research on depression.

Cite This Study

Cheng et al. (2025) studied this question.

synapsesocial.com/papers/68d43906713b0b5dfea78904https://doi.org/10.1038/s41386-025-02242-9
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Also Consider

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  4. 4Polygenic scores for depression are associated with indices of neighborhood adversity.2025
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