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September 19, 2025Acta chimica slovenica

Synthesis, DFT, and Molecular Docking Studies of Anti-cancer Imidazolidine-2,4-dione and Thiazolidine-2,4-dione Derivatives

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Authors

OAOsama Alharbi

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Implication

New thiazolidine-2,4-dione and imidazolidine-2,4-dione derivatives showed promising antitumor activity against Caco-2 cells, suggesting their potential as cancer treatments.

Key Points

  • Compounds 13b and 13c demonstrated notable antitumor activity with IC50 values of 41.30 ± 0.07 μM and 109.2 ± 0.027 μM, respectively.
  • New derivatives of thiazolidine-2,4-dione and imidazolidine-2,4-dione were synthesized and evaluated for their biological activity.
  • Computational methods included DFT calculations and molecular docking to assess the properties of the synthesized compounds.
  • These findings provide insights into the potential of these compounds as therapeutic agents in cancer treatment.

Cite This Study

Osama Alharbi (2025) studied this question.

synapsesocial.com/papers/68d437f0713b0b5dfea77544https://doi.org/10.17344/acsi.2025.9326
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