August 26, 2025ChemistrySelect

Synthesis, Antiproliferative Activity Evaluation, and Computational Insights of Benzodimidazol‐2(3H)‐one Derivatives

View Full Paper

Ask AI

Bookmark

Authors

GDGulay DilekBülent Ecevit University MMMuhammed Tılahun Muhammed SASenem AkkoçBahçeşehir University

Discussion

Member takes

Implication

Lab evaluation of cytotoxic activity against cancer cell lines suggests benzo[ d ]imidazol derivatives may target cancer proteins, highlighting potential in treatment.

Key Points

Compound 3a showed higher cytotoxic activity, particularly targeting DLD-1 colon cancer cells, compared to other derivatives.
Molecular docking revealed 3a's potential binding ability to cancer proteins, though weaker than the standard drug irinotecan.
Using molecular dynamics, the stability of protein-compound complexes was confirmed, supporting continued binding in targeted areas.
Density functional theory calculations indicated that chemical stability was highest for derivative 2a among the synthesized compounds.

Cite This Study

Dilek et al. (2025) studied this question.

synapsesocial.com/papers/68af7dfe7567bf4f94ff5607 https://doi.org/10.1002/slct.202503640

View Full Paper

Ask AI

Bookmark

Implication

Lab evaluation of cytotoxic activity against cancer cell lines suggests benzo[ d ]imidazol derivatives may target cancer proteins, highlighting potential in treatment.

Synthesis, Antiproliferative Activity Evaluation, and Computational Insights of Benzodimidazol‐2(3H)‐one Derivatives

Discussion

Member takes

Implication

Key Points

Cite This Study

Synthesis, Antiproliferative Activity Evaluation, and Computational Insights of Benzodimidazol‐2(3H)‐one Derivatives

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider