Severe Aplastic Anemia Following Epstein-Barr Virus Reactivation in a Previously Healthy Adolescent

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The patient developed severe aplastic anemia linked to Epstein-Barr virus reactivation, indicating serious complications.
Bone marrow biopsy confirmed aplastic anemia; 45% mortality observed in literature review of pediatric cases.
Diagnosis primarily based on serology, with EBV reactivation showing higher mortality compared to primary infection.
Urgent clinical evaluation for EBV-related marrow failure is crucial in pediatric patients with febrile pancytopenia.

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Case report highlights aplastic anemia caused by Epstein-Barr virus reactivation in a 12-year-old girl, suggesting urgent need for awareness.

Viscarra et al. (2025) studied this question.

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Case report highlights aplastic anemia caused by Epstein-Barr virus reactivation in a 12-year-old girl, suggesting urgent need for awareness.