Dapagliflozin attenuates lipotoxic tenocyte injury via PPARα activation and irisin-driven antioxidant pathways

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Dapagliflozin significantly reduced apoptosis in palmitate-exposed tenocytes, indicating protective effects against lipotoxic injury.
Western blotting revealed that dapagliflozin upregulated PPARα and antioxidant enzyme activities, reducing oxidative stress markers.
Gene silencing of PPARα negated the protective benefits of dapagliflozin, highlighting its essential role in cellular resilience.
Irisin, upregulated by dapagliflozin, further helped to mitigate oxidative stress and promote tenocyte viability.

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This study demonstrates that dapagliflozin reduces oxidative stress and apoptosis in tenocytes, suggesting promising metabolic regulation strategies.

Pyo et al. (2025) studied this question.

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This study demonstrates that dapagliflozin reduces oxidative stress and apoptosis in tenocytes, suggesting promising metabolic regulation strategies.