What question did this study set out to answer?

This research aims to understand how dapagliflozin and exercise together affect heart structure and function in rats.

June 12, 2026European Journal of Preventive CardiologyOpen Access

Interaction of dapagliflozin and exercise in a small animal model: functional, sarcomeric, and proteomic insights

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Why the study?

Does dapagliflozin combined with exercise improve cardiac morphology and sarcomeric function in a rat model of exercise-induced cardiovascular remodeling?

Key Points

This research aims to understand how dapagliflozin and exercise together affect heart structure and function in rats.
Male Wistar rats were divided into four groups: controls, exercised, Dapa-treated, and exercised+Dapa.
Rats underwent 12 weeks of swim training with daily dapagliflozin administration (1 mg/kg).
Left ventricular function was analyzed via echocardiography, cardiomyocyte force generation, and proteomic profiling.
Exercise improved physiological hypertrophy and systolic function without affecting heart mass.
Combined exercise and dapagliflozin treatment enhanced contractility and force generation in cardiomyocytes.
Proteomics identified significant changes in proteins related to metabolism, redox regulation, and cardiovascular signaling.

Structured PICO

Does dapagliflozin combined with exercise improve cardiac morphology and sarcomeric function in a rat model of exercise-induced cardiovascular remodeling?

Population

Male Wistar rats in a model of exercise-induced cardiovascular remodeling

Intervention

Dapagliflozin (1 mg/kg daily) combined with 12 weeks of swim training

Comparator

Controls (no exercise, no dapagliflozin), exercise alone, and dapagliflozin alone

Outcome

Cardiac morphology, sarcomeric function, and proteomic alterationssurrogate

Dapagliflozin and exercise induce distinct but complementary molecular adaptations that synergistically enhance systolic function and sarcomeric performance in a rat model.

Discussion

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Implication

May support combined dapagliflozin-exercise strategies in HF models; leaves open clinical translation from rat data.

Cite This Study

Kolodziejska et al. (2026) studied this question.

synapsesocial.com/papers/6a2bd11d6550ea4541ffe892 https://doi.org/10.1093/eurjpc/zwag249.380

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