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September 17, 2025PharmaceuticalsOpen Access

Preclinical Evaluation of Nanoemulsion and Polymeric Nanocapsule Delivery Systems of 4-(Phenylselanyl)-2H-Chromen-2-One for Rheumatoid Arthritis and Comorbidities

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Authors

CFCaren Aline Ramson da FonsecaVPVinícius Costa PradoLCLetícia Cruz

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Overview

Innovative delivery systems for 4-(phenylselanyl)-2H-chromen-2-one improve outcomes in rheumatoid arthritis, highlighting novel therapeutic strategies.

Key Points

  • Both nanoemulsified and nanoencapsulated formulations showed significant inhibitory effects on rheumatoid arthritis symptoms.
  • 4-PSCO NC and NE formulations effectively reduced inflammation and pain, while restoring acetylcholinesterase activity in mice.
  • Treatment with 4-PSCO NC led to decreased oxidative stress levels, suggesting enhanced neuroprotective benefits.
  • The study identifies polymeric nanocapsules as a promising strategy for managing both RA symptoms and underlying pathology.

Cite This Study

Fonseca et al. (2025) studied this question.

synapsesocial.com/papers/68d42c58713b0b5dfea6fd3ahttps://doi.org/10.3390/ph18091379
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