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July 31, 2025PharmaceuticsOpen Access

From Structure to Function: The Promise of PAMAM Dendrimers in Biomedical Applications

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Authors

SASaid Alamos-MusreDBDaniel Beltrán-ChacanaJMJuan Moyano

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Overview

Review uncovers diverse endocytic pathways for PAMAM dendrimers in drug delivery, suggesting optimization needed for cytotoxicity management.

Key Points

  • PAMAM dendrimers are versatile nanoparticles used in drug and gene delivery, with significant potential in cancer therapy.
  • They can be internalized into cells via various endocytic mechanisms, enhancing their effectiveness.
  • Cytotoxicity of these nanoparticles depends on their structure, including size and surface charge, requiring careful modification.
  • The review highlights optimization strategies for dendrimer use, aiming to improve bioavailability and reduce toxicity in biomedical applications.

Cite This Study

Alamos-Musre et al. (2025) studied this question.

synapsesocial.com/papers/689a0c5fe6551bb0af8cf6c0https://doi.org/10.3390/pharmaceutics17070927
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