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September 17, 2025Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition

Impacts of Cerebral Iron Accumulation on Cognitive Changes and Motor Dysfunction in Aging: A Quantitative Susceptibility Mapping (QSM) Study

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Authors

JBJonghyun BaeZGZhaoyuan GongAGAlex Guo

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Overview

This quantitative study finds iron accumulation linked to cognitive decline and motor dysfunction in aging.

Key Points

  • Higher iron levels are associated with accelerated cognitive decline, indicating a crucial relationship with aging.
  • QSM values show a significant correlation with cognitive performance and gait speed over time.
  • Utilizing quantitative susceptibility mapping, the study provides insights into aging processes and brain health.
  • The findings suggest that targeting iron accumulation could be vital for developing therapies for neurodegenerative diseases.

Cite This Study

Bae et al. (2025) studied this question.

synapsesocial.com/papers/68d42c46713b0b5dfea6f4e7https://doi.org/10.58530/2025/4369
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Imaging of Cerebral Iron as an Emerging Marker for Brain Aging, Neurodegeneration, and Cerebrovascular Diseases2025 · 6 citations
  2. 2Cerebral iron load and cognitive impairment: the Atherosclerosis Risk in Communities (ARIC) Study2025
  3. 3Early extra-motor brain iron accumulation is linked to cognitive deficits in sporadic early-stage amyotrophic lateral sclerosis patients2025
  4. 4Quantitative assessment of iron and magnetic susceptibility in cortical regions of the same older adults2025
  5. 5Increased iron deposition in the PCC of older women with aMCI2025