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September 10, 2025Brain SciencesOpen Access

Imaging of Cerebral Iron as an Emerging Marker for Brain Aging, Neurodegeneration, and Cerebrovascular Diseases

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Authors

CZC. ZhouYZYi‐Cheng Zhu

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Overview

This review highlights the role of cerebral iron and QSM in assessing neurodegeneration and cerebrovascular diseases.

Key Points

  • Cerebral iron accumulation correlates with motor and cognitive impairments in neurodegenerative conditions.
  • Quantitative susceptibility mapping captures distinct patterns of iron distribution linked to disease progression.
  • Iron dysregulation is implicated in conditions such as Alzheimer's, Parkinson's, and cerebrovascular disease, necessitating further study.
  • Understanding iron dynamics in the brain could enable better monitoring and interventions for age-related pathologies.

Cite This Study

Zhou et al. (2025) studied this question.

synapsesocial.com/papers/68c243acb210217d647a7c9dhttps://doi.org/10.3390/brainsci15090944
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Impacts of Cerebral Iron Accumulation on Cognitive Changes and Motor Dysfunction in Aging: A Quantitative Susceptibility Mapping (QSM) Study2025
  2. 2Quantitative assessment of iron and magnetic susceptibility in cortical regions of the same older adults2025
  3. 3Imaging Developmental Trajectories of Laminar Magnetic Susceptibility Throughout Adulthood in Human Brain Cortex2025 · 1 citations
  4. 4Early extra-motor brain iron accumulation is linked to cognitive deficits in sporadic early-stage amyotrophic lateral sclerosis patients2025
  5. 5Investigation of Iron Deposition Metabolism in Alzheimer’s Disease in Hippocampal Subregions using QSM-MRI2025