Meta-analysis reveals disrupted reward circuits in individuals with substance use disorder, suggesting shared neural mechanisms.
Motivation: The changes in cortical-striatal-thalamic-cortical functional connectivity patterns may be a common neural mechanism in substance addicted patients. Goal(s): The present study aim to identify common neural patterns in patients with substance use disorder. Approach: The seed-based D-mapping toolkit was used to analyzed connectivity patterns in key brain regions of the reward circuit, including the anterior cingulate cortex, prefrontal cortex, striatum, thalamus, and amygdala. Results: The present study identifies disruptions in two critical reward circuits: the cortical-striatal-thalamic-cortical circuit and the cortical-striatal-hippocampus/parahippocampal gyrus-amygdala-cortical circuit. Impact: All substance use disorder individuals have the same neural mechanism, which is the disruption of reward circuits.
No takes yet. Share an insight, caveat, or question.
Feifei Zhang (2025) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: