Determinants of Cognitive and Brain Resilience to Reduced Neuronal Metabolism in Alzheimer’s Disease: A Longitudinal Whole-Brain MRSI Study

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Education and brain volume significantly moderated the relationship between neuronal metabolism and cognitive decline.
Participants included 150 individuals, with 41 diagnosed with mild cognitive impairment and 109 with Alzheimer's disease.
Longitudinal analysis employed whole-brain proton magnetic resonance spectroscopic imaging to measure neuronal metabolism.
These findings underscore the potential of educational interventions in enhancing cognitive resilience despite neuronal dysfunction.

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Longitudinal study highlights how education and brain volume impact cognitive resilience in Alzheimer's disease.

Li et al. (2025) studied this question.

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