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September 16, 2025MedicineOpen Access

Network pharmacology analysis and clinical efficacy study of Fuzi Lizhong Decoction combined with XELOX plus sintilimab in the treatment of advanced gastric cancer

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Authors

WZWei ZhangWHWei HuJJJinxing Ji

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Overview

Network pharmacology analysis shows improved clinical efficacy in advanced gastric cancer when Fuzi Lizhong Decoction is combined with XELOX and sintilimab, suggesting enhanced health outcomes.

Key Points

  • Combining Fuzi Lizhong Decoction with XELOX and sintilimab significantly improves clinical outcomes in advanced gastric cancer.
  • The study identifies 732 targets for Fuzi Lizhong Decoction involved in protein phosphorylation and signal transduction.
  • Molecular docking reveals strong binding between key targets and the monomers from Fuzi Lizhong Decoction.
  • Clinical comparisons show reductions in traditional symptom scores and tumor marker levels with the combined treatment.

Cite This Study

Zhang et al. (2025) studied this question.

synapsesocial.com/papers/68d4232f713b0b5dfea6b3dbhttps://doi.org/10.1097/md.0000000000044262
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Also Consider

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  4. 4Novel multitarget-labeled molecular networking for exploring pharmacodynamic compounds of traditional Chinese medicine formulae: a case study of Zhu-Ling decoction.2025
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