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September 20, 2025

Novel multitarget-labeled molecular networking for exploring pharmacodynamic compounds of traditional Chinese medicine formulae: a case study of Zhu-Ling decoction.

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Authors

XLXianxian LiJMJiamu MaYZYuan Zheng

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Overview

Case study identifies key compounds in zhu-ling decoction for chronic glomerulonephritis, suggesting novel therapeutic potentials.

Key Points

  • The multitarget-labeled molecular networking approach successfully identifies important pharmacodynamic compounds in zhu-ling decoction.
  • Results reveal that poricoic acid A and polyporusterone A bind effectively to key targets like TGF-β and IL-6.
  • Application of HPLC-Q-Exactive MS aids in discovering a total of 98 compounds associated with zhu-ling decoction.
  • Findings emphasize the potential of traditional chinese medicine in addressing chronic glomerulonephritis through synergistic effects.

Cite This Study

Li et al. (2025) studied this question.

synapsesocial.com/papers/68d43a00713b0b5dfea7a290https://doi.org/10.1039/d5ay00772k
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