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September 16, 2025European PsychiatryOpen Access

Effectiveness of Psychotherapy vs Antidepressants for Depression in Primary Care in India: A Randomized Pilot Trial

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Authors

JPJulia R PozueloALAvijit LahiriRSRahul Singh

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Overview

Randomized pilot trial reveals comparable effectiveness of behavioral activation and fluoxetine in moderate to severe depression in primary care settings.

Key Points

  • Both psychotherapy based on behavioral activation and antidepressant fluoxetine effectively reduce PHQ-9 scores in participants.
  • Retention rates were high, with 79% of participants adhering to treatment protocols and completing the study.
  • The pilot trial successfully demonstrated feasibility and acceptability, setting the stage for a larger precision trial.
  • Challenges and facilitators identified will help refine methodologies for future larger-scale studies.

Cite This Study

Pozuelo et al. (2025) studied this question.

synapsesocial.com/papers/68d4219a713b0b5dfea69fcdhttps://doi.org/10.1192/j.eurpsy.2025.795
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  1. 1Scaling up the task-sharing of an evidence-based psychological treatment for depression in rural India: an implementation study2025
  2. 2A comparative analysis of fluoxetine and amitriptyline in depression: assessing effectiveness and adherence in a rural hospital setting2025
  3. 3A Conversational Agent (PracticePal) to Support the Delivery of a Brief Behavioral Activation Treatment for Depression in Rural India: Development and Pilot-Testing Study2025
  4. 4A Conversational Agent (PracticePal) to Support the Delivery of a Brief Behavioral Activation Treatment for Depression in Rural India: Development and Pilot-Testing Study (Preprint)2025
  5. 5Psychiatric Medications Procurement at Primary Health Centers (PHCs) in Tumkur: Insights from an Effectiveness Implementation Hybrid Randomized Controlled Trial on Mental Health Tele-mentoring of Primary Care Doctors (PCDs)2025