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August 22, 2025International Journal of Basic & Clinical PharmacologyOpen Access

A comparative analysis of fluoxetine and amitriptyline in depression: assessing effectiveness and adherence in a rural hospital setting

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Authors

RDR. DhanalakshmiKAK. ArunkumarATAli Tahmasebi

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Overview

Observational analysis shows fluoxetine improved adherence and effectiveness in patients with depression, highlighting its advantages.

Key Points

  • Fluoxetine exhibited a greater mean reduction in Hamilton depression rating scores compared to amitriptyline, improving patient outcomes.
  • A significant correlation between medication adherence and treatment effectiveness was observed in patients using both antidepressants.
  • This prospective observational study included 126 patients newly diagnosed with depression from a rural hospital setting.
  • Results suggest that higher medication adherence leads to better clinical outcomes, marking fluoxetine as a preferred choice over amitriptyline.

Cite This Study

Dhanalakshmi et al. (2025) studied this question.

synapsesocial.com/papers/68af76bf7567bf4f94fefcdehttps://doi.org/10.18203/2319-2003.ijbcp20252577
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