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September 13, 2025Immunopharmacology and Immunotoxicology

All- trans retinoic acid ameliorates S100-induced experimental autoimmune hepatitis by regulating the Treg/Th17 balance

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Authors

HZH. ZhaoYLYang LuoQLQiang Li

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Overview

Experimental analysis shows all-trans retinoic acid enhances Treg cells and diminishes Th17 cells, indicating a potential therapy for autoimmune hepatitis.

Key Points

  • AtRA improved the Treg/Th17 balance in mice with S100-induced experimental autoimmune hepatitis.
  • Intraperitoneal injection of 25 mg/kg AtRA dramatically decreased liver inflammation and CD4+ T cell infiltration.
  • Immunofluorescence staining and flow cytometry confirmed changes in Treg and Th17 cell populations in the liver and spleen.
  • AtRA administration resulted in lower serum IL-6 levels and suppressed the activation of the STAT3 signaling pathway.

Cite This Study

Zhao et al. (2025) studied this question.

synapsesocial.com/papers/68d41ee7713b0b5dfea68645https://doi.org/10.1080/08923973.2025.2554663
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