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September 10, 2025Clinical & Experimental Immunology

Vitamin A deficiency enhances susceptibility to experimental autoimmune pancreatitis through activation of CD4+ T cells expressing CXCR3 and secreting CCL25

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Authors

MKMasayuki KurimotoTWTomohiro WatanabeYOYasuo Otsuka

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Overview

Experimental autoimmune pancreatitis increased with vitamin A deficiency, suggesting retinoic acid limits T cell accumulation.

Key Points

  • Vitamin A deficiency elevates susceptibility to autoimmune pancreatitis through CD4+ T cell activation, promoting inflammation.
  • Activated dendritic cells in the pancreas facilitate the recruitment of CD4+ T cells by producing important chemokines.
  • Analysis of T cell behavior revealed that CD4+CXCR3+ T cells released CCL25, indicating a pathway in autoimmune activity.
  • These findings support that retinoic acid can modulate immune responses in autoimmune pancreatitis by inhibiting T cell accumulation.

Cite This Study

Kurimoto et al. (2025) studied this question.

synapsesocial.com/papers/68c23d3ab210217d6478d623https://doi.org/10.1093/cei/uxaf060
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