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September 12, 2025Frontiers in OncologyOpen Access

Editorial: Formation of immunological niches in tumor microenvironments: mechanisms and therapeutic potential

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Authors

ZCZilu ChenQLQingyu LuoWLWeiling Li

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Overview

This editorial uncovers mechanisms of immunological niches in tumor microenvironments, highlighting their role in immune evasion and therapeutic strategies.

Key Points

  • Immunological niches within tumors regulate anti-tumor immunity while promoting immune evasion and therapy resistance.
  • Evidence shows that distinct niche architectures significantly influence immunotherapy responses across various cancer types.
  • Therapeutic strategies that target niche biology can potentially overcome therapeutic resistance and improve clinical outcomes.
  • Clinical translation of niche-derived biomarkers is transforming patient stratification and treatment selection in precision oncology.

Cite This Study

Chen et al. (2025) studied this question.

synapsesocial.com/papers/68d41ed2713b0b5dfea67815https://doi.org/10.3389/fonc.2025.1675697
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