September 12, 2025Brain Research BulletinOpen Access

Mutation of ube3a causes developmental abnormalities and autism-like molecular and behavioral alterations in zebrafish

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Authors

GDGodfried Dougnon LRLana Rummel HMHideaki Matsui

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Overview

This study demonstrates developmental abnormalities and behavioral changes in zebrafish with UBE3A mutation, suggesting links to neurodevelopmental disorders.

Key Points

Developmental abnormalities were noted in zebrafish models with a mutation in the ube3a gene, causing significant implications for neurodevelopment.
Behavioral analyses indicated locomotor deficits and reduced social interactions in mutant zebrafish, aligning with profiles seen in neurodevelopmental disorders.
RNA sequencing revealed dysregulation of critical genes associated with chromatin and protein-DNA interactions, highlighting the mutation's molecular impact.
The findings establish zebrafish as a viable model for studying UBE3A-related neurodevelopment and behavior alterations, aiming to elucidate its role in disorders.

Cite This Study

Dougnon et al. (2025) studied this question.

synapsesocial.com/papers/68d41dae713b0b5dfea67446 https://doi.org/10.1016/j.brainresbull.2025.111542

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September 12, 2025Brain Research BulletinOpen Access

Mutation of ube3a causes developmental abnormalities and autism-like molecular and behavioral alterations in zebrafish

View Full Paper

Ask AI

Bookmark

Authors

GDGodfried Dougnon LRLana Rummel HMHideaki Matsui

Discussion

Member takes

Overview

This study demonstrates developmental abnormalities and behavioral changes in zebrafish with UBE3A mutation, suggesting links to neurodevelopmental disorders.

Key Points

Developmental abnormalities were noted in zebrafish models with a mutation in the ube3a gene, causing significant implications for neurodevelopment.
Behavioral analyses indicated locomotor deficits and reduced social interactions in mutant zebrafish, aligning with profiles seen in neurodevelopmental disorders.
RNA sequencing revealed dysregulation of critical genes associated with chromatin and protein-DNA interactions, highlighting the mutation's molecular impact.
The findings establish zebrafish as a viable model for studying UBE3A-related neurodevelopment and behavior alterations, aiming to elucidate its role in disorders.

Cite This Study

Dougnon et al. (2025) studied this question.

synapsesocial.com/papers/68d41dae713b0b5dfea67446 https://doi.org/10.1016/j.brainresbull.2025.111542

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