Mutation of Brain Aromatase Impairs Behavior and Neuroplasticity in Adult Zebrafish

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Gene editing revealed that brain aromatase influences behavior, neuroplasticity, and gene expression in zebrafish.

Significant behavioral abnormalities were observed in mutant zebrafish, particularly altered swimming activity and sociability.
The cyp19a1b mutation resulted in decreased cell proliferation in certain brain regions, while other areas showed increased activity.
Transcriptomic analysis indicated widespread dysregulation of gene expression linked to neuroplasticity and behavioral changes.
Findings suggest that brain aromatase plays a critical role in regulating behavior and neurobiology of zebrafish, with sex differences noted.

Malleret et al. (2025) studied this question.

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