September 12, 2025Journal of Nuclear MedicineOpen Access

How Rapidly Does the FAPI PET Signal Reverse Following Therapy? Assessing the FAPI PET Signal in Hypertensive Cardiac Injury and Fibrosis in Mice

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Authors

AHAtefeh HosseiniUniversity of Kansas EHElias Haj‐YehiaEssen University Hospital SKSebastian KorsteWest German Heart and Vascular Center Essen

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Implication

This analysis reveals how FAPI PET detects fibrosis changes in hypertensive cardiac injury, suggesting its potential in assessing treatment responses.

Key Points

The FAPI PET signal quickly declines after therapy withdrawal, indicating dynamic changes in fibroblast activity.
Significant 68Ga-FAPI-46 uptake was observed at 1 week in treated mice, illustrating its efficacy in assessing cardiac fibrosis.
Ang-II/PE infusion resulted in noticeable myocardial and liver changes, highlighting the potential of FAPI PET for monitoring treatment effects.
Early detection of fibrosis through FAPI PET could inform timely interventions in the progression of heart failure.

Cite This Study

Hosseini et al. (2025) studied this question.

synapsesocial.com/papers/68d41c02713b0b5dfea652f5 https://doi.org/10.2967/jnumed.124.268860

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Implication

This analysis reveals how FAPI PET detects fibrosis changes in hypertensive cardiac injury, suggesting its potential in assessing treatment responses.

How Rapidly Does the FAPI PET Signal Reverse Following Therapy? Assessing the FAPI PET Signal in Hypertensive Cardiac Injury and Fibrosis in Mice

Discussion

Member takes

Implication

Key Points

Cite This Study

How Rapidly Does the FAPI PET Signal Reverse Following Therapy? Assessing the FAPI PET Signal in Hypertensive Cardiac Injury and Fibrosis in Mice

Discussion

Member takes

Implication

Key Points

Cite This Study

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