September 12, 2025Open Access

Factors Influencing Letrozole Response in Ovulation Induction among Polycystic Ovary Syndrome Women

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Retrospective study finds antral follicle count predicts ovulation response in PCOS women, indicating treatment optimization.

Letrozole induces ovulation in 83.3% of women with polycystic ovary syndrome, demonstrating a significant response rate.
Of 327 women analyzed, antral follicle count emerged as the only independent predictor of non-response with a specific cut-off.
Women with an AFC below 35 demonstrated a higher likelihood of responding well to Letrozole, suggesting improved treatment pathways.
Logistic regression and ROC analysis were utilized, indicating the importance of AFC in individualizing ovulation induction treatments.

Acharya et al. (2025) studied this question.

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