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September 12, 2025CureusOpen Access

Comparative Effectiveness and Safety of Intravenous Versus Oral Iron Therapy With Iron-Deficient Heart Failure: A Network Meta-Analysis of Randomized Controlled Trials

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Authors

PPParag N PatelDMDaya Krishan MangalDSDidar Singh

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Overview

Network meta-analysis reveals intravenous iron improves functional outcomes in heart failure patients with iron deficiency, suggesting it may reduce hospitalization risks.

Key Points

  • Intravenous iron therapy significantly improved six-minute walk distance compared to placebo, with a mean difference of +26.0 m.
  • Oral iron therapy had a comparable mean improvement in six-minute walk distance, but results were not statistically significant, showing inconsistency.
  • Analysis included 13 randomized controlled trials focusing on heart failure patients, evaluating various iron formulations and assessing multiple clinical outcomes.
  • Findings indicate intravenous iron as the preferred option to enhance symptoms and decrease hospitalizations in patients with iron deficiency heart failure.

Cite This Study

Patel et al. (2025) studied this question.

synapsesocial.com/papers/68d418db713b0b5dfea647eahttps://doi.org/10.7759/cureus.92087
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Iron supplementation in heart failure and iron deficiency: does it help?2025 · 3 citations
  2. 2Intravenous Iron in Heart Failure Patients With Iron Deficiency: A Meta-Analysis of Randomized Controlled Trials.2025
  3. 3Comparative Effectiveness of Intravenous Ferric Carboxymaltose, Ferric Derisomaltose, and Iron Sucrose in Heart Failure With Reduced Ejection Fraction: A Network Meta-Analysis of 15 Randomized Trials2025 · 1 citations
  4. 4Intravenous ferric carboxymaltose in heart failure with iron deficiency (<scp>FAIR</scp>‐<scp>HF2 DZHK05</scp> trial): Sex‐specific outcomes2025 · 6 citations
  5. 5Real-World Review of Adherence to Guideline-Directed Intravenous Iron Therapy in Heart Failure Patients: A Retrospective Observational Study from a Tertiary Care Hospital in Oman2025