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September 23, 2025Open Access

Effect of Post‑Induction Treadmill Exercise on Hippocampal Agrin and Laminin in a Rat Model of Alzheimer’s Disease: Relevance to Hippocampal Sclerosis

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Authors

AKAmin KananiMSM. Sha SadeghiARAliasghar Ravasi

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Overview

Moderate treadmill exercise improves hippocampal agrin and laminin levels in rats with Alzheimer’s disease, suggesting cognitive benefits.

Key Points

  • Treadmill exercise enhances hippocampal agrin and laminin levels, indicating synaptic stability.
  • Increased agrin and laminin levels were significant with p ≤ 0.001 when compared to untreated Aβ rats.
  • Spatial learning and memory were evaluated using the Morris water maze, revealing cognitive improvements.
  • Exercise may have implications for hippocampal sclerosis, relevant to aging and dementia disorders.

Cite This Study

Kanani et al. (2025) studied this question.

synapsesocial.com/papers/68d43ed1713b0b5dfea7e2dfhttps://doi.org/10.20944/preprints202509.1680.v1
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