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September 11, 2025CureusOpen Access

Facial Presentation of Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type: A Rare Case

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Authors

RMR. MadaniWestern Michigan UniversityMSMohamed SaidAin Shams UniversityTATalal Al-AssilWestern Michigan University

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Implication

Clinical analysis reveals primary cutaneous diffuse large B-cell lymphoma in an unusual facial location, suggesting the need for broader diagnostic considerations.

Key Points

  • A solitary ulcerated facial lesion led to the diagnosis of primary cutaneous diffuse large B-cell lymphoma.
  • The patient was successfully treated with R-CHOP chemotherapy and radiation, achieving complete remission after nearly 10 years.
  • This case underscores the importance of considering cutaneous lymphoma in differential diagnoses for unusual skin lesions.
  • Early and appropriate treatment can lead to successful outcomes, even in atypical presentations of this aggressive lymphoma.

Cite This Study

Madani et al. (2025) studied this question.

synapsesocial.com/papers/68d418cd713b0b5dfea64126https://doi.org/10.7759/cureus.92001
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Unexpected Diagnosis in a Cutaneous Tumoral Lesion: Primary Cutaneous Leg-Type B-Cell Lymphoma2025
  2. 2Primary Cutaneous Diffuse Large B-cell Lymphoma, Leg Type with Immune Thrombocytopenia as the First Primary Presentation2025
  3. 3Unusual Presentation of Primary Cardiac Lymphoma in a 61‐Year‐Old Woman: A Case Report2025
  4. 4Plasmablastic Lymphoma Presenting With Multiple Cutaneous Nodules Mimicking Primary Cutaneous Marginal Zone Lymphoma2026
  5. 5Clinical and Therapeutic Challenges in Aggressive Diffuse Large B-Cell Lymphoma of Immune-Privileged Sites: A Case Report of Orbital and Cervical Involvement in an End-Stage Renal Disease (ESRD) Patient2025