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September 11, 2025Open Access

Macropinocytosis-Mediated Recyclable LYTACs (McR-TACs) for Membrane and Extracellular Protein Degradation

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Authors

PLPeixin LiuYLYule LiYYY You

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Overview

Innovative recyclable LYTACs enable protein degradation in a receptor-independent manner, suggesting broader application potential.

Key Points

  • The McR-TAC platform effectively degrades both membrane and extracellular proteins, enabling more versatile applications.
  • By utilizing macropinocytosis, these recyclable LYTACs demonstrate a novel approach to protein degradation without receptor dependence.
  • This advancement in recyclable protein degraders showcases enhanced durability and feasibility of existing lysosome-targeting technologies.
  • The study highlights an innovative method by harnessing endogenous transport pathways for protein degradation.

Cite This Study

Liu et al. (2025) studied this question.

synapsesocial.com/papers/68d41711713b0b5dfea62aa2https://doi.org/10.1101/2025.09.08.674971
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