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September 11, 2025Inflammatory Bowel Diseases

Branched-Chain Amino Acids Exacerbate Colitis Progression by Lowering Colonic Fumarate Levels

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Authors

AMAna Mendes‐FriasMVMargarida C. VieiraMAMarta Araújo

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Overview

Experimental evidence shows BCAAs worsen colitis severity in mice, indicating links to colonic fumarate levels and microbiota.

Key Points

  • BCAA supplementation worsens ulcerative colitis severity in mice, affecting immune cell populations and microbiota.
  • Significant increases in the disease activity index were observed with branched-chain amino acids during colitis induction.
  • Metabolomic profiling revealed lowered colonic fumarate levels and shifts in gut microbiome composition with BCAA treatment.
  • Dimethyl fumarate treatment improved disease outcomes, highlighting its potential in managing BCAA-induced colitis exacerbation.

Cite This Study

Mendes‐Frias et al. (2025) studied this question.

synapsesocial.com/papers/68d413ff713b0b5dfea61fe2https://doi.org/10.1093/ibd/izaf125
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Also Consider

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