September 10, 2025

MicroRNA-372-3p impairs fatty acid metabolism in hepatocellular carcinoma cells by targeting

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Overexpression of microRNA-372-3p significantly reduces cell proliferation and invasion in hepatocellular carcinoma cells.
Transcriptomic analysis identified 1,759 downregulated genes, notably affecting fatty acid oxidation pathways.
High-resolution imaging revealed reduced interactions between lipid droplets and mitochondria in miR-372-3p-overexpressing cells.
Direct targeting of CPT1A and ACSL4 by microRNA-372-3p links it to impaired lipid metabolism.

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Overexpression of microRNA-372-3p reduces tumor growth in hepatocellular carcinoma, indicating implications for fatty acid oxidation therapies.

Phetkong et al. (2025) studied this question.

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Overexpression of microRNA-372-3p reduces tumor growth in hepatocellular carcinoma, indicating implications for fatty acid oxidation therapies.