September 10, 2025Frontiers in PhysiologyOpen Access

MicroRNA-18a-5p regulates hepatic lipid accumulation in response to high-fat diet

View Full Paper

Ask AI

Bookmark

miR-18a-5p downregulation contributes to lipid accumulation and ER stress in MASLD.
In HFD-fed rats, miR-18a-5p levels were significantly lower, coinciding with increased SREBP1c expression.
Overexpression of miR-18a-5p reduced hepatic lipid accumulation and apoptosis in both models.
Identifying miR-18a-5p's role may support novel treatments for metabolic liver diseases.

Discussion

No takes yet. Share an insight, caveat, or question.

Experimental analysis shows miR-18a-5p regulates lipid levels in MASLD models, indicating therapeutic potential.

Petito et al. (2025) studied this question.

View Full Paper

Ask AI

Bookmark